P-139 Comparison of clinical outcomes between two hyaluronan-rich transfer medium

Abstract Study question Is there any difference in effect on clinical outcomes after single vitrified-warmed blastocyst transfer day 5 using two hyaluronan-rich medium? Summary answer There was no significant rates of pregnancy, implantation and miscarriage between medium. What is known already Hyaluronan one the glycosaminoglycan that naturally present female reproductive organs promotes endometrial stroma preimplantation embryo adhesion through CD44 glycoprotein receptors. Several studies demonstrated use hyaluronan-enriched medium women receiving either cleavage-stage or blastocyst-stage improved compared to standard However, according containing different concentrations hyaluronan are still insufficient. design, size, duration A retrospective study 1047 cycles with normal responders (aged 23-35 years) conducted from September 2018 November 2022. All were evaluated. Only first IVF attempts included. had undergone a GnRH antagonist protocol. Cycles divided into groups: Group (n = 511, EmbryoGlue®, Vitrolife) B 536, UTMTM, Origio). Participants/materials, setting, methods graded Gardner Schoolcraft’s criteria. The blastocysts equilibrated for an average 47 minutes transfers until transfer. blasotcyst then loaded catheter (COOK® medical). groups. Statistical analyses Chi-square test Independent t-test SPSS. Main results role chance differences mean age (31.6 ± 2.5 vs. 31.8 2.3, P 0.432), thickness (10.4 1.4 10.3 1.3, 0.478), oocytes retrieved (20.8 6.8 20.5 6.9, 0.470) number transferred good-quality stage rate (≥BB grade, 74.8% 72.6%, 0.423) We also observed similar biochemical pregnancy (79.5% 78.0%, 0.562), (71.4% 69.2%, 0.434), (72.4% 70.3%, 0.459), ongoing (67.5% 66.2%, 0.659), (5.5% 4.3%, 0.463) multiple (1.4% 1.6%, 0.782) B, respectively. Limitations, reasons caution This limited by its nature single-center absence live birth information. investigated only have data reliability. Therefore, further needed evaluate our 6 7. Wider implications findings showed hyaluronan. Our could implication selection appropriate commercial laboratory conditions. Trial registration not applicable